| 3. Round | 11/02/2023 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 7. Round | 14/03/2023 | Guaraní | - | Tacuary | 1:0 | ||||
| 8. Round | 19/03/2023 | Sportivo Trinidense | - | Guaraní | 1:1 |  |
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| 10. Round | 01/04/2023 | Club Olimpia | - | Guaraní | 0:1 | |
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| 11. Round | 11/04/2023 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 13. Round | 17/04/2023 | Sportivo Ameliano | - | Guaraní | 1:1 | |
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| 15. Round | 29/04/2023 | Guaraní | - | Resistencia SC | 1:0 | |
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| 22. Round | 10/06/2023 | General Caballero DJLM | - | Guaraní | 0:0 |
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