| 1. Round | 20/08/2017 | Montevideo Wanderers | - | Danubio | 1:3 | ||||
| 2. Round | 27/08/2017 | Danubio | - | Nacional | 1:1 | ||||
| 3. Round | 02/09/2017 | Fénix | - | Danubio | 0:1 | ||||
| 4. Round | 09/09/2017 | Danubio | - | Rampla Juniors | 1:1 | ||||
| 5. Round | 16/09/2017 | Defensor Sporting | - | Danubio | 1:0 | ||||
| 9. Round | 08/11/2017 | Danubio | - | Plaza Colonia | 2:2 | ||||
| 10. Round | 11/11/2017 | River Plate | - | Danubio | 1:1 |  |
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| 11. Round | 16/11/2017 | Danubio | - | Peñarol | 0:2 | ||||
| 12. Round | 19/11/2017 | Racing | - | Danubio | 5:2 |
Uruguay