2. Round | 13/03/2021 | Atlético Palmaflor | - | Real Santa Cruz | 1:0 | ||||
7. Round | 07/05/2021 | Real Santa Cruz | - | Blooming | 1:0 | ||||
8. Round | 12/07/2021 | Bolívar | - | Real Santa Cruz | 1:1 | ||||
11. Round | 26/07/2021 | Real Santa Cruz | - | San José | 5:0 | ||||
15. Round | 15/08/2021 | The Strongest | - | Real Santa Cruz | 1:2 | ||||
19. Round | 18/09/2021 | Real Santa Cruz | - | Royal Pari | 2:1 | ||||
21. Round | 27/09/2021 | Real Santa Cruz | - | CD Guabirá | 3:0 | ||||
25. Round | 01/11/2021 | Real Santa Cruz | - | Real Tomayapo | 2:0 | ||||
28. Round | 01/12/2021 | Real Santa Cruz | - | Nacional Potosí | 1:1 | ||||
30. Round | 12/12/2021 | Real Santa Cruz | - | The Strongest | 1:0 |