| Group I | 16/09/2010 | PSV Eindhoven | - | Sampdoria | 1:1 | ||||
| Group I | 30/09/2010 | Metalist Kharkiv | - | PSV Eindhoven | 0:2 |  |
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| Group I | 21/10/2010 | Debreceni VSC | - | PSV Eindhoven | 1:2 | ||||
| Group I | 04/11/2010 | PSV Eindhoven | - | Debreceni VSC | 3:0 | ||||
| Group I | 01/12/2010 | Sampdoria | - | PSV Eindhoven | 1:2 | |
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| Group I | 16/12/2010 | PSV Eindhoven | - | Metalist Kharkiv | 0:0 | ||||
| 2. Round | 17/02/2011 | Lille OSC | - | PSV Eindhoven | 2:2 | ||||
| 2. Round | 24/02/2011 | PSV Eindhoven | - | Lille OSC | 3:1 |  |
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| Round of 16 | 10/03/2011 | PSV Eindhoven | - | Rangers FC | 0:0 | ||||
| Round of 16 | 17/03/2011 | Rangers FC | - | PSV Eindhoven | 0:1 | ||||
| Quarter-finals | 07/04/2011 | SL Benfica | - | PSV Eindhoven | 4:1 | ||||
| Quarter-finals | 14/04/2011 | PSV Eindhoven | - | SL Benfica | 2:2 | |
Brazil
