| 4. Round | 10/10/2020 | Cafessa Jalisco | - | Azores de Hidalgo | 0:0 | ||||
| 10. Round | 22/11/2020 | Cafessa Jalisco | - | CD Cuautla | 2:2 | ||||
| 11. Round | 29/11/2020 | Deportivo Dongu | - | Cafessa Jalisco | 0:1 |  |
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| 12. Round | 06/12/2020 | Cafessa Jalisco | - | Aguacateros CDU | 4:1 | ||||
| 13. Round | 12/12/2020 | Pioneros de Cancún | - | Cafessa Jalisco | 0:3 | ||||
| 3. Round | 16/12/2020 | Zitácuaro | - | Cafessa Jalisco | 1:3 | |
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| 14. Round | 17/01/2021 | Cafessa Jalisco | - | Inter Playa | 0:2 |  |
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| 16. Round | 02/02/2021 | Cafessa Jalisco | - | Zitácuaro | 2:0 | ||||
| 19. Round | 19/02/2021 | Club Irapuato | - | Cafessa Jalisco | 0:0 | ||||
| 24. Round | 01/04/2021 | Cafessa Jalisco | - | Deportivo Dongu | 1:0 | ||||
| 25. Round | 03/04/2021 | Aguacateros CDU | - | Cafessa Jalisco | 1:0 | ||||
| 26. Round | 10/04/2021 | Cafessa Jalisco | - | Pioneros de Cancún | 0:0 | |
Mexico