| 1. Round | 02/07/2022 | Mazatlán FC | - | Puebla FC | 2:4 | ||||
| 2. Round | 09/07/2022 | Mazatlán FC | - | UANL Tigres | 0:1 |  |
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| 3. Round | 19/07/2022 | CF Pachuca | - | Mazatlán FC | 1:1 | ||||
| 4. Round | 23/07/2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | ||||
| 6. Round | 31/07/2022 | Club Tijuana | - | Mazatlán FC | 2:0 | ||||
| 7. Round | 06/08/2022 | Mazatlán FC | - | Deportivo Guadalajara | 2:1 | ||||
| 9. Round | 17/08/2022 | Mazatlán FC | - | Gallos Blancos | 1:1 | ||||
| 10. Round | 21/08/2022 | FC Juárez | - | Mazatlán FC | 1:1 | ||||
| 11. Round | 27/08/2022 | Mazatlán FC | - | CF América | 1:3 | |
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| 17. Round | 03/10/2022 | Santos Laguna | - | Mazatlán FC | 3:0 |
Mexico
