| 1. Round | 25/07/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 3. Round | 08/08/2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
| 4. Round | 14/08/2021 | Pumas UNAM | - | Gallos Blancos | 0:0 | ||||
| 5. Round | 18/08/2021 | Club Necaxa | - | Pumas UNAM | 3:0 | ||||
| 6. Round | 22/08/2021 | Pumas UNAM | - | Puebla FC | 2:0 | ||||
| 7. Round | 29/08/2021 | Deportivo Toluca | - | Pumas UNAM | 2:1 | ||||
| 8. Round | 12/09/2021 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 | ||||
| 9. Round | 19/09/2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
| 14. Round | 21/10/2021 | Club León | - | Pumas UNAM | 1:2 |  |
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| 15. Round | 24/10/2021 | Pumas UNAM | - | Club Tijuana | 3:1 |
Mexico