| 7. Round | 04/09/2021 | Club Tijuana [U16] | - | CF América [U16] | 2:1 | ||||
| 8. Round | 11/09/2021 | Gallos Blancos [U16] | - | Club Tijuana [U16] | 1:2 | ||||
| 2. Round | 15/09/2021 | Club Tijuana [U16] | - | Deportivo Toluca [U16] | 3:0 | ||||
| 9. Round | 18/09/2021 | Club Tijuana [U16] | - | Pumas UNAM [U16] | 1:0 | ||||
| 11. Round | 02/10/2021 | Deportivo Toluca [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 15. Round | 30/10/2021 | Club Tijuana [U16] | - | Gallos Blancos [U16] | 3:2 |
Mexico