1. Round | 05/02/2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
2. Round | 11/02/2022 | Tacuary | - | 12 de Octubre de Itauguá | 1:1 | ||||
3. Round | 19/02/2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
4. Round | 27/02/2022 | Tacuary | - | Libertad | 0:1 | ||||
6. Round | 11/03/2022 | Sportivo Ameliano | - | Tacuary | 0:2 | ||||
7. Round | 21/03/2022 | Tacuary | - | Club Nacional | 2:1 | ||||
8. Round | 04/04/2022 | Guaraní | - | Tacuary | 1:2 | ||||
9. Round | 11/04/2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
10. Round | 19/04/2022 | Sol de América | - | Tacuary | 1:0 | ||||
15. Round | 11/05/2022 | Libertad | - | Tacuary | 3:0 | ||||
16. Round | 16/05/2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 | ||||
19. Round | 19/06/2022 | Tacuary | - | Guaraní | 0:2 |