1. Round | 17/07/2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
2. Round | 22/07/2022 | Guaraní | - | General Caballero DJLM | 2:1 | ||||
3. Round | 26/07/2022 | Resistencia SC | - | Guaraní | 0:0 | ||||
4. Round | 31/07/2022 | Guaraní | - | 12 de Octubre de Itauguá | 0:1 | ||||
5. Round | 07/08/2022 | Sol de América | - | Guaraní | 1:0 | ||||
6. Round | 14/08/2022 | Guaraní | - | Club Nacional | 1:1 | ||||
7. Round | 21/08/2022 | Cerro Porteño | - | Guaraní | 1:1 | ||||
8. Round | 27/08/2022 | Libertad | - | Guaraní | 2:2 | ||||
9. Round | 02/09/2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
10. Round | 11/09/2022 | Tacuary | - | Guaraní | 2:0 | ||||
11. Round | 15/09/2022 | Guaraní | - | Sportivo Ameliano | 2:1 | ||||
12. Round | 20/09/2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
13. Round | 24/09/2022 | General Caballero DJLM | - | Guaraní | 3:0 | ||||
17. Round | 17/10/2022 | Club Nacional | - | Guaraní | 2:0 |