| 18. Round | 11/09/2021 | Royal Pari | - | Club San José | 6:1 | ||||
| 19. Round | 17/09/2021 | Club San José | - | Real Potosí | 0:0 | ||||
| 20. Round | 21/09/2021 | CD Guabirá | - | Club San José | 4:0 | ||||
| 21. Round | 25/09/2021 | Club San José | - | Blooming | 1:2 | ||||
| 22. Round | 20/10/2021 | Bolívar | - | Club San José | 4:1 | ||||
| 23. Round | 22/10/2021 | Club San José | - | Club Aurora | 1:4 | ||||
| 24. Round | 27/10/2021 | Real Tomayapo | - | Club San José | 1:0 | ||||
| 25. Round | 01/11/2021 | Independiente Petrolero | - | Club San José | 4:0 | ||||
| 26. Round | 22/11/2021 | Club San José | - | Real Santa Cruz | 1:2 | ||||
| 27. Round | 26/11/2021 | Nacional Potosí | - | Club San José | 7:1 | ||||
| 28. Round | 30/11/2021 | Club San José | - | Oriente Petrolero | 0:2 | ||||
| 29. Round | 05/12/2021 | The Strongest | - | Club San José | 2:0 |
Bolivia