| 11. Round | 06/11/2021 | Aalborg BK [Youth] | - | Esbjerg fB [Youth] | 3:4 | ||||
| 12. Round | 20/11/2021 | Esbjerg fB [Youth] | - | SønderjyskE [Youth] | 3:6 | ||||
| 13. Round | 26/11/2021 | Odense BK [Youth] | - | Esbjerg fB [Youth] | 3:1 | ||||
| 17. Round | 12/03/2022 | Aarhus GF [Youth] | - | Esbjerg fB [Youth] | 0:4 | ||||
| 18. Round | 02/04/2022 | Esbjerg fB [Youth] | - | Lyngby BK [Youth] | 2:0 | ||||
| 19. Round | 09/04/2022 | FC Nordsjælland [Youth] | - | Esbjerg fB [Youth] | 2:2 | ||||
| 20. Round | 13/04/2022 | Randers SK Freja [Youth] | - | Esbjerg fB [Youth] | 1:0 | ||||
| 21. Round | 23/04/2022 | Esbjerg fB [Youth] | - | Aalborg BK [Youth] | 3:3 | ||||
| 23. Round | 07/05/2022 | Esbjerg fB [Youth] | - | AC Horsens [Youth] | 0:1 | ||||
| 24. Round | 14/05/2022 | Esbjerg fB [Youth] | - | FC Midtjylland [Youth] | 2:1 | ||||
| 26. Round | 18/05/2022 | Esbjerg fB [Youth] | - | Odense BK [Youth] | 2:2 |
Denmark