| 1. Round | 30/07/2000 | FK Drnovice | - | Chmel Blsany | 1:3 | ||||
| 2. Round | 06/08/2000 | FK Drnovice | - | 1. FC Synot Stare Mesto | 0:2 | ||||
| 3. Round | 13/08/2000 | Viktoria Plzeň | - | FK Drnovice | 2:1 | ||||
| 4. Round | 20/08/2000 | FK Drnovice | - | CU Bohemians Praha | 2:1 |  |
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| 5. Round | 28/08/2000 | Slovan Liberec | - | FK Drnovice | 2:0 | ||||
| 6. Round | 08/09/2000 | FK Drnovice | - | Baník Ostrava | 3:0 | ||||
| 7. Round | 16/09/2000 | AC Sparta Praha | - | FK Drnovice | 3:0 | ||||
| 8. Round | 22/09/2000 | FK Drnovice | - | FK Teplice | 3:1 | ||||
| 10. Round | 15/10/2000 | FK Drnovice | - | FC Marila Příbram | 0:1 | ||||
| 11. Round | 22/10/2000 | FC Stavo Artikel Brno | - | FK Drnovice | 0:0 | ||||
| 12. Round | 29/10/2000 | FK Drnovice | - | Viktoria Žižkov | 2:2 | ||||
| 13. Round | 05/11/2000 | FK Jablonec 97 | - | FK Drnovice | 0:0 |  |
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| 14. Round | 12/11/2000 | FK Drnovice | - | Dynamo České Budějovice | 2:0 | |
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| 15. Round | 18/11/2000 | Slavia Praha | - | FK Drnovice | 0:0 | ||||
| 16. Round | 26/11/2000 | Chmel Blsany | - | FK Drnovice | 0:0 |
Slovakia