| 1. Round | 08/08/2020 | MFK Ružomberok | - | AS Trenčín | 2:2 | ||||
| 2. Round | 11/08/2020 | Spartak Trnava | - | MFK Ružomberok | 3:1 | ||||
| 3. Round | 15/08/2020 | MFK Ružomberok | - | ŠKF Sereď | 0:0 | ||||
| 4. Round | 22/08/2020 | FC Nitra | - | MFK Ružomberok | 1:1 |  |
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| 5. Round | 30/08/2020 | MFK Ružomberok | - | FK Pohronie | 0:0 | ||||
| 6. Round | 12/09/2020 | FC DAC 1904 | - | MFK Ružomberok | 3:2 | ||||
| 7. Round | 19/09/2020 | MFK Ružomberok | - | MFK Zemplín Michalovce | 4:0 |  |
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| 8. Round | 26/09/2020 | Slovan Bratislava | - | MFK Ružomberok | 5:0 | |
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| 17. Round | 12/12/2020 | MFK Ružomberok | - | FC DAC 1904 | 1:1 | ||||
| 18. Round | 16/12/2020 | MFK Zemplín Michalovce | - | MFK Ružomberok | 4:3 | |
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| 19. Round | 13/02/2021 | MFK Ružomberok | - | Slovan Bratislava | 0:0 | ||||
| 20. Round | 20/02/2021 | Zlaté Moravce | - | MFK Ružomberok | 3:1 | ||||
| 21. Round | 27/02/2021 | MFK Ružomberok | - | FK Senica | 2:3 | |
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| 22. Round | 06/03/2021 | MŠK Žilina | - | MFK Ružomberok | 3:2 |
Slovakia