| 1. Round | 27/03/2022 | Deportivo Cuenca [Women] | - | Leones del Norte [Women] | 0:3 | ||||
| 2. Round | 02/04/2022 | Leones del Norte [Women] | - | Macará [Women] | 1:2 |  |
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| 5. Round | 29/04/2022 | Espuce FC [Women] | - | Leones del Norte [Women] | 2:1 | ||||
| 7. Round | 14/05/2022 | Dragonas IDV [Women] | - | Leones del Norte [Women] | 4:1 | ||||
| 10. Round | 03/06/2022 | Leones del Norte [Women] | - | Emelec [Women] | 4:1 | ||||
| 11. Round | 12/06/2022 | Ñañas [Women] | - | Leones del Norte [Women] | 4:1 | ||||
| 13. Round | 30/07/2022 | Quito FC [Women] | - | Leones del Norte [Women] | 1:0 |
Ecuador