| 1. Round | 05/05/2021 | Sport JC [Women] | - | San Miguel [Women] | 1:1 | ||||
| 2. Round | 12/05/2021 | San Miguel [Women] | - | LDU Quito [Women] | 0:5 | ||||
| 6. Round | 05/06/2021 | San Miguel [Women] | - | Quito FC [Women] | 3:2 | ||||
| 7. Round | 12/06/2021 | Dragonas IDV [Women] | - | San Miguel [Women] | 2:4 |  |
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| 8. Round | 19/06/2021 | San Miguel [Women] | - | Sport JC [Women] | 2:0 | ||||
| 9. Round | 26/06/2021 | LDU Quito [Women] | - | San Miguel [Women] | 5:0 | ||||
| 10. Round | 03/07/2021 | San Miguel [Women] | - | El Nacional [Women] | 1:0 | ||||
| 11. Round | 10/07/2021 | Ñañas [Women] | - | San Miguel [Women] | 2:1 | |
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| 12. Round | 17/07/2021 | San Miguel [Women] | - | Espuce FC [Women] | 2:1 | ||||
| 13. Round | 25/07/2021 | Quito FC [Women] | - | San Miguel [Women] | 3:1 |
Colombia