| 1. Round | 27/03/2022 | Deportivo Cuenca [Women] | - | Leones del Norte [Women] | 0:3 |  |
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| 2. Round | 02/04/2022 | Leones del Norte [Women] | - | Macará [Women] | 1:2 |  |
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| 3. Round | 16/04/2022 | Emelec [Women] | - | Leones del Norte [Women] | 0:1 | |
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| 4. Round | 22/04/2022 | Leones del Norte [Women] | - | Ñañas [Women] | 1:2 | |
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| 5. Round | 29/04/2022 | Espuce FC [Women] | - | Leones del Norte [Women] | 2:1 | ||||
| 6. Round | 06/05/2022 | Leones del Norte [Women] | - | Quito FC [Women] | 3:3 | |
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| 7. Round | 14/05/2022 | Dragonas IDV [Women] | - | Leones del Norte [Women] | 4:1 | ||||
| 8. Round | 20/05/2022 | Leones del Norte [Women] | - | Deportivo Cuenca [Women] | 3:0 | ||||
| 9. Round | 28/05/2022 | Macará [Women] | - | Leones del Norte [Women] | 1:0 | ||||
| 10. Round | 03/06/2022 | Leones del Norte [Women] | - | Emelec [Women] | 4:1 | |
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| 12. Round | 23/07/2022 | Leones del Norte [Women] | - | Espuce FC [Women] | 0:0 | ||||
| 13. Round | 30/07/2022 | Quito FC [Women] | - | Leones del Norte [Women] | 1:0 | |
Colombia