| 1. Round | 05/02/2022 | Fénix | - | Peñarol | 1:0 | ||||
| 2. Round | 11/02/2022 | Montevideo City Torque | - | Fénix | 1:2 | ||||
| 3. Round | 20/02/2022 | Fénix | - | Montevideo Wanderers | 0:3 | ||||
| 4. Round | 25/02/2022 | Plaza Colonia | - | Fénix | 1:1 | ||||
| 6. Round | 20/03/2022 | River Plate | - | Fénix | 3:1 | ||||
| 7. Round | 03/04/2022 | Fénix | - | Cerro Largo | 2:0 | ||||
| 10. Round | 24/04/2022 | Fénix | - | Albion | 2:1 |  |
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| 11. Round | 09/05/2022 | Nacional | - | Fénix | 1:0 |
Uruguay