| 1. Round | 11/07/2022 | FC Juárez [Women] | - | Cruz Azul [Women] | 1:2 | ||||
| 2. Round | 16/07/2022 | Cruz Azul [Women] | - | UANL Tigres [Women] | 0:0 | ||||
| 5. Round | 31/07/2022 | Atlético San Luis [Women] | - | Cruz Azul [Women] | 2:1 | ||||
| 6. Round | 06/08/2022 | Cruz Azul [Women] | - | Santos Laguna [Women] | 0:1 | ||||
| 9. Round | 24/08/2022 | CF América [Women] | - | Cruz Azul [Women] | 3:0 | ||||
| 11. Round | 09/09/2022 | Pumas UNAM [Women] | - | Cruz Azul [Women] | 2:2 | ||||
| 14. Round | 25/09/2022 | Cruz Azul [Women] | - | Club Tijuana [Women] | 1:1 | ||||
| 15. Round | 30/09/2022 | Gallos Blancos [Women] | - | Cruz Azul [Women] | 0:1 | ||||
| 17. Round | 24/10/2022 | Deportivo Guadalajara [Women] | - | Cruz Azul [Women] | 3:0 |
Mexico