| 1. Round | 22/08/2021 | HVV Hollandia | - | VV UNA | 0:2 | ||||
| 2. Round | 29/08/2021 | JOS Watergraafsmeer | - | HVV Hollandia | 1:0 | ||||
| 3. Round | 05/09/2021 | HVV Hollandia | - | EVV | 0:0 |  |
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| 4. Round | 12/09/2021 | VV Gemert | - | HVV Hollandia | 3:0 | ||||
| 5. Round | 19/09/2021 | HVV Hollandia | - | OFC Oostzaan | 1:1 | ||||
| 6. Round | 26/09/2021 | HSC'21 | - | HVV Hollandia | 2:2 | ||||
| 7. Round | 03/10/2021 | RKVV DEM | - | HVV Hollandia | 0:2 | ||||
| 8. Round | 10/10/2021 | HVV Hollandia | - | RKSV Groene Ster | 3:0 | ||||
| 9. Round | 17/10/2021 | OSS '20 | - | HVV Hollandia | 3:1 | ||||
| 10. Round | 31/10/2021 | HVV Hollandia | - | VV Hoogland | 0:1 | ||||
| 11. Round | 07/11/2021 | Blauw Geel '38 | - | HVV Hollandia | 4:0 | ||||
| 12. Round | 14/11/2021 | HVV Hollandia | - | RKVV Westlandia | 2:0 | ||||
| 13. Round | 21/11/2021 | USV Hercules | - | HVV Hollandia | 2:0 | ||||
| 15. Round | 20/02/2022 | Unitas Gorinchem | - | HVV Hollandia | 0:3 | ||||
| 16. Round | 27/02/2022 | HVV Hollandia | - | VV Dongen | 0:2 | ||||
| 14. Round | 09/03/2022 | HVV Hollandia | - | ADO '20 | 0:1 | ||||
| 20. Round | 27/03/2022 | RKSV Groene Ster | - | HVV Hollandia | 3:1 | ||||
| 33. Round | 29/05/2022 | EVV | - | HVV Hollandia | 1:0 | ||||
| 34. Round | 06/06/2022 | HVV Hollandia | - | VV Gemert | 2:1 |
Netherlands