| 2. Round | 07/07/2022 | Blooming | - | Real Santa Cruz | 5:1 |  |
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| 3. Round | 09/07/2022 | Real Santa Cruz | - | Atlético Palmaflor | 0:0 | |
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| 4. Round | 16/07/2022 | Real Tomayapo | - | Real Santa Cruz | 1:2 | ||||
| 5. Round | 23/07/2022 | Real Santa Cruz | - | Oriente Petrolero | 2:1 | ||||
| 7. Round | 01/08/2022 | Real Santa Cruz | - | Club Aurora | 1:1 | ||||
| 8. Round | 05/08/2022 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
| 9. Round | 10/08/2022 | Real Santa Cruz | - | The Strongest | 0:3 | ||||
| 10. Round | 13/08/2022 | Real Santa Cruz | - | Bolívar | 1:2 | ||||
| 11. Round | 20/08/2022 | Independiente Petrolero | - | Real Santa Cruz | 1:0 | ||||
| 12. Round | 23/08/2022 | Real Santa Cruz | - | Royal Pari | 2:1 | ||||
| 14. Round | 01/09/2022 | Real Santa Cruz | - | Jorge Wilstermann | 0:0 | ||||
| 17. Round | 10/09/2022 | Real Santa Cruz | - | Blooming | 1:3 | ||||
| 18. Round | 16/09/2022 | Atlético Palmaflor | - | Real Santa Cruz | 4:0 | ||||
| 19. Round | 30/09/2022 | Real Santa Cruz | - | Real Tomayapo | 1:1 | ||||
| 20. Round | 06/10/2022 | Oriente Petrolero | - | Real Santa Cruz | 3:1 | |
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| 22. Round | 13/10/2022 | Club Aurora | - | Real Santa Cruz | 1:2 | ||||
| 23. Round | 16/10/2022 | Real Santa Cruz | - | Always Ready | 1:0 |
Bolivia