| 1. Round | 23/01/2010 | Nacional | - | Cerro Largo | 3:1 |  |
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| 2. Round | 29/01/2010 | Tacuarembó | - | Nacional | 1:1 | |
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| 3. Round | 06/02/2010 | Nacional | - | Defensor Sporting | 0:1 | |
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| 5. Round | 19/02/2010 | Nacional | - | River Plate | 1:4 | ||||
| 6. Round | 28/02/2010 | Racing | - | Nacional | 0:3 | ||||
| 7. Round | 06/03/2010 | Nacional | - | Montevideo Wanderers | 2:1 | |
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| 9. Round | 21/03/2010 | Central Español | - | Nacional | 0:2 | |
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| 10. Round | 27/03/2010 | CA Cerro | - | Nacional | 3:1 |  |
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| 12. Round | 11/04/2010 | Nacional | - | Danubio | 2:1 | |
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Uruguay
Spain