| 3. Round | 04/10/2020 | Club Irapuato | - | Deportivo Dongu | 2:0 | ||||
| 4. Round | 10/10/2020 | Aguacateros CDU | - | Club Irapuato | 0:4 | ||||
| 11. Round | 27/11/2020 | Inter Playa | - | Club Irapuato | 2:0 | ||||
| 7. Round | 02/12/2020 | Club Irapuato | - | Cafetaleros de Chiapas | 4:2 |  |
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| 12. Round | 06/12/2020 | Club Irapuato | - | Club de Ciervos | 0:0 | ||||
| 13. Round | 11/12/2020 | Cañoneros Marina | - | Club Irapuato | 1:2 | ||||
| 1. Round | 16/12/2020 | Club Irapuato | - | Cruz Azul Hidalgo | 0:2 | ||||
| 14. Round | 16/01/2021 | Cruz Azul Hidalgo | - | Club Irapuato | 2:2 | ||||
| 16. Round | 30/01/2021 | Deportivo Dongu | - | Club Irapuato | 0:7 | ||||
| 17. Round | 05/02/2021 | Club Irapuato | - | Aguacateros CDU | 1:3 | ||||
| 18. Round | 12/02/2021 | Pioneros de Cancún | - | Club Irapuato | 0:3 | |
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| 19. Round | 19/02/2021 | Club Irapuato | - | Cafessa Jalisco | 0:0 | ||||
| 20. Round | 01/03/2021 | Cafetaleros de Chiapas | - | Club Irapuato | 0:0 | ||||
| 25. Round | 03/04/2021 | Club de Ciervos | - | Club Irapuato | 0:3 |
Mexico