| 5. Round | 27/08/2021 | 1. FC Nürnberg | - | Karlsruher SC | 2:1 | ||||
| 10. Round | 17/10/2021 | Dynamo Dresden | - | 1. FC Nürnberg | 0:1 | ||||
| 12. Round | 29/10/2021 | SV Darmstadt 98 | - | 1. FC Nürnberg | 2:0 | ||||
| 16. Round | 04/12/2021 | 1. FC Nürnberg | - | Holstein Kiel | 2:1 | ||||
| 18. Round | 18/12/2021 | Erzgebirge Aue | - | 1. FC Nürnberg | 1:3 | ||||
| 20. Round | 21/01/2022 | Fortuna Düsseldorf | - | 1. FC Nürnberg | 0:1 | ||||
| 21. Round | 04/02/2022 | 1. FC Nürnberg | - | FC Ingolstadt 04 | 0:5 | ||||
| 22. Round | 12/02/2022 | Karlsruher SC | - | 1. FC Nürnberg | 4:1 | ||||
| 23. Round | 19/02/2022 | 1. FC Nürnberg | - | Jahn Regensburg | 2:0 | ||||
| 24. Round | 26/02/2022 | Hansa Rostock | - | 1. FC Nürnberg | 0:2 | ||||
| 25. Round | 05/03/2022 | 1. FC Nürnberg | - | Hamburger SV | 2:1 | ||||
| 33. Round | 08/05/2022 | Holstein Kiel | - | 1. FC Nürnberg | 3:0 |
Germany