| 3. Round | 30/01/2022 | CD Zap | - | Cafetaleros de Chiapas | 1:4 | ||||
| 4. Round | 04/02/2022 | Inter Playa | - | CD Zap | 3:2 |  |
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| 5. Round | 12/02/2022 | Inter de Querétaro | - | CD Zap | 0:3 | ||||
| 6. Round | 20/02/2022 | CD Zap | - | Montañeses FC | 0:1 | ||||
| 7. Round | 26/02/2022 | Leviatán FC | - | CD Zap | 0:4 | ||||
| 9. Round | 13/03/2022 | Yalmakan FC | - | CD Zap | 1:1 | ||||
| 11. Round | 27/03/2022 | Reboceros de La Piedad | - | CD Zap | 1:2 |
Mexico