| 1. Round | 21/08/2021 | Paphos FC | - | APOEL Nikosia | 4:0 | ||||
| 3. Round | 19/09/2021 | Apollon Limassol | - | APOEL Nikosia | 2:1 | ||||
| 5. Round | 03/10/2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 6. Round | 18/10/2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 7. Round | 24/10/2021 | Aris Limassol | - | APOEL Nikosia | 0:1 | ||||
| 8. Round | 30/10/2021 | Doxa Katokopias | - | APOEL Nikosia | 2:2 | ||||
| 9. Round | 06/11/2021 | APOEL Nikosia | - | AEL Limassol | 3:0 | ||||
| 10. Round | 22/11/2021 | AEK Larnaca | - | APOEL Nikosia | 0:0 |  |
|||
| 12. Round | 05/12/2021 | APOEL Nikosia | - | Paphos FC | 1:1 | |
|||
| 11. Round | 26/12/2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | ||||
| 17. Round | 15/01/2022 | Ethnikos Achna | - | APOEL Nikosia | 0:3 | ||||
| 18. Round | 23/01/2022 | APOEL Nikosia | - | Aris Limassol | 1:1 |
Norway