| 1. Round | 05/03/2022 | Tatran Liptovský Mikuláš | - | FK Senica | 2:1 | ||||
| 2. Round | 12/03/2022 | FK Senica | - | MFK Zemplín Michalovce | 2:1 |  |
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| 3. Round | 19/03/2022 | AS Trenčín | - | FK Senica | 4:1 | ||||
| 4. Round | 02/04/2022 | Zlaté Moravce | - | FK Senica | 3:2 | |
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| 5. Round | 09/04/2022 | FK Senica | - | FK Pohronie | 2:1 | ||||
| 8. Round | 30/04/2022 | FK Senica | - | Zlaté Moravce | 0:0 | ||||
| 9. Round | 14/05/2022 | FK Senica | - | AS Trenčín | 0:3 | |
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| 10. Round | 21/05/2022 | FK Pohronie | - | FK Senica | 1:0 |
Slovakia