| 1. Round | 07/11/2021 | Levadiakos | - | Asteras Vlachioti | 2:1 | ||||
| 2. Round | 14/11/2021 | Asteras Vlachioti | - | AS Rhodos | 0:0 | ||||
| 3. Round | 20/11/2021 | AO Episkopi | - | Asteras Vlachioti | 0:1 | ||||
| 7. Round | 12/12/2021 | Panathinaikos II | - | Asteras Vlachioti | 2:0 | ||||
| 8. Round | 15/12/2021 | Asteras Vlachioti | - | AE Karaiskakis | 1:1 |  |
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| 9. Round | 19/12/2021 | Ergotelis | - | Asteras Vlachioti | 0:0 | ||||
| 26. Round | 26/03/2022 | Asteras Vlachioti | - | Ergotelis | 4:0 | ||||
| 28. Round | 03/04/2022 | Diagoras FC | - | Asteras Vlachioti | 2:0 | ||||
| 31. Round | 13/04/2022 | Asteras Vlachioti | - | OFI Ierapetra | 4:1 | ||||
| 33. Round | 27/04/2022 | Asteras Vlachioti | - | AO Egaleo | 2:1 | ||||
| 34. Round | 01/05/2022 | Irodotos | - | Asteras Vlachioti | 2:1 |
Greece