| 2. Round | 30/07/2021 | ŠKF Sereď | - | MFK Ružomberok | 2:3 | ||||
| 4. Round | 13/08/2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 5. Round | 21/08/2021 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
| 6. Round | 28/08/2021 | MFK Ružomberok | - | MFK Zemplín Michalovce | 0:0 | ||||
| 7. Round | 10/09/2021 | Zlaté Moravce | - | MFK Ružomberok | 2:2 | ||||
| 12. Round | 23/10/2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
| 13. Round | 30/10/2021 | MFK Ružomberok | - | ŠKF Sereď | 3:1 |  |
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| 14. Round | 07/11/2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 15. Round | 19/11/2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Round | 28/11/2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
| 17. Round | 04/12/2021 | MFK Zemplín Michalovce | - | MFK Ružomberok | 0:3 | ||||
| 18. Round | 11/12/2021 | MFK Ružomberok | - | Zlaté Moravce | 1:1 | ||||
| 19. Round | 17/12/2021 | FC DAC 1904 | - | MFK Ružomberok | 0:0 | ||||
| 20. Round | 14/02/2022 | MFK Ružomberok | - | MŠK Žilina | 5:1 | |
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| 21. Round | 19/02/2022 | Tatran Liptovský Mikuláš | - | MFK Ružomberok | 3:2 | |
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| 22. Round | 26/02/2022 | MFK Ružomberok | - | FK Pohronie | 1:0 |  |
Slovakia