| 1. Round | 17/07/2022 | MFK Skalica | - | MFK Ružomberok | 0:2 | ||||
| 2. Round | 22/07/2022 | Zlaté Moravce | - | MFK Skalica | 2:2 | ||||
| 3. Round | 30/07/2022 | MFK Skalica | - | AS Trenčín | 2:0 | ||||
| 4. Round | 07/08/2022 | Slovan Bratislava | - | MFK Skalica | 3:0 | ||||
| 6. Round | 20/08/2022 | MFK Zemplín Michalovce | - | MFK Skalica | 3:1 | ||||
| 7. Round | 27/08/2022 | MFK Skalica | - | Spartak Trnava | 1:1 | ||||
| 8. Round | 30/08/2022 | MFK Skalica | - | MŠK Žilina | 1:0 |  |
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| 9. Round | 03/09/2022 | Tatran Liptovský Mikuláš | - | MFK Skalica | 0:0 | ||||
| 10. Round | 10/09/2022 | MFK Skalica | - | FC DAC 1904 | 1:1 | ||||
| 11. Round | 16/09/2022 | Dukla Banská Bystrica | - | MFK Skalica | 0:0 | |
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| 12. Round | 30/09/2022 | MFK Ružomberok | - | MFK Skalica | 2:0 | ||||
| 14. Round | 15/10/2022 | AS Trenčín | - | MFK Skalica | 3:1 | ||||
| 15. Round | 21/10/2022 | MFK Skalica | - | Slovan Bratislava | 1:4 | ||||
| 16. Round | 29/10/2022 | FK Železiarne Podbrezová | - | MFK Skalica | 0:2 | ||||
| 17. Round | 05/11/2022 | MFK Skalica | - | MFK Zemplín Michalovce | 0:0 | |
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| 19. Round | 11/02/2023 | MŠK Žilina | - | MFK Skalica | 1:0 | ||||
| 20. Round | 19/02/2023 | MFK Skalica | - | Tatran Liptovský Mikuláš | 3:0 | ||||
| 21. Round | 25/02/2023 | FC DAC 1904 | - | MFK Skalica | 2:1 |  |
Slovakia