| 2. Round | 29/07/2017 | MŠK Žilina | - | 1. FC Tatran Prešov | 2:3 | ||||
| 4. Round | 12/08/2017 | MFK Zemplín Michalovce | - | 1. FC Tatran Prešov | 0:1 | ||||
| 5. Round | 19/08/2017 | Zlaté Moravce | - | 1. FC Tatran Prešov | 4:1 | ||||
| 6. Round | 26/08/2017 | 1. FC Tatran Prešov | - | FK Senica | 2:2 | ||||
| 8. Round | 16/09/2017 | 1. FC Tatran Prešov | - | Spartak Trnava | 0:2 | ||||
| 9. Round | 19/09/2017 | FK Železiarne Podbrezová | - | 1. FC Tatran Prešov | 2:0 | ||||
| 10. Round | 24/09/2017 | 1. FC Tatran Prešov | - | AS Trenčín | 0:7 | ||||
| 11. Round | 01/10/2017 | MFK Ružomberok | - | 1. FC Tatran Prešov | 3:1 | ||||
| 12. Round | 14/10/2017 | Slovan Bratislava | - | 1. FC Tatran Prešov | 3:2 | ||||
| 19. Round | 09/12/2017 | Spartak Trnava | - | 1. FC Tatran Prešov | 1:0 |  |
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| 20. Round | 18/02/2018 | 1. FC Tatran Prešov | - | FK Železiarne Podbrezová | 0:2 | ||||
| 21. Round | 24/02/2018 | AS Trenčín | - | 1. FC Tatran Prešov | 2:0 |
Slovakia