| 1. Round | 06/02/2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Round | 13/02/2022 | Boston River | - | Cerrito | 0:1 | ||||
| 8. Round | 10/04/2022 | Boston River | - | Nacional | 0:6 | ||||
| 10. Round | 24/04/2022 | Boston River | - | Deportivo Maldonado | 2:0 |  |
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| 13. Round | 21/05/2022 | Peñarol | - | Boston River | 1:0 | ||||
| 14. Round | 28/05/2022 | Boston River | - | Montevideo City Torque | 3:1 | ||||
| 15. Round | 06/06/2022 | Montevideo Wanderers | - | Boston River | 1:2 |
Uruguay