| 1. Round | 30/07/2022 | Plaza Colonia | - | Boston River | 1:1 | ||||
| 2. Round | 06/08/2022 | Cerrito | - | Boston River | 0:3 | ||||
| 3. Round | 12/08/2022 | Boston River | - | River Plate | 1:2 | ||||
| 6. Round | 21/08/2022 | Defensor Sporting | - | Boston River | 0:1 |  |
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| 4. Round | 04/09/2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 8. Round | 15/09/2022 | Nacional | - | Boston River | 1:0 | ||||
| 9. Round | 19/09/2022 | Boston River | - | Danubio | 0:1 | ||||
| 11. Round | 02/10/2022 | Boston River | - | Rentistas | 3:0 |  |
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| 12. Round | 09/10/2022 | Liverpool | - | Boston River | 3:2 | ||||
| 13. Round | 12/10/2022 | Boston River | - | Peñarol | 2:1 | ||||
| 15. Round | 24/10/2022 | Boston River | - | Montevideo Wanderers | 2:2 |
Uruguay