| 1. Round | 16/01/2021 | Danubio | - | Cerro Largo | 0:3 | ||||
| 2. Round | 20/01/2021 | Cerro Largo | - | Nacional | 0:0 | ||||
| 3. Round | 29/01/2021 | Boston River | - | Cerro Largo | 2:1 | ||||
| 4. Round | 02/02/2021 | Cerro Largo | - | Deportivo Maldonado | 1:2 | ||||
| 5. Round | 06/02/2021 | Rentistas | - | Cerro Largo | 2:1 | ||||
| 6. Round | 10/02/2021 | Liverpool | - | Cerro Largo | 3:2 | ||||
| 8. Round | 17/02/2021 | Cerro Largo | - | Peñarol | 1:1 | ||||
| 9. Round | 20/02/2021 | River Plate | - | Cerro Largo | 2:0 | ||||
| 10. Round | 01/03/2021 | Montevideo City Torque | - | Cerro Largo | 0:0 | ||||
| 11. Round | 07/03/2021 | Cerro Largo | - | Plaza Colonia | 3:1 |  |
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| 12. Round | 14/03/2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 13. Round | 21/03/2021 | Fénix | - | Cerro Largo | 1:0 | ||||
| 14. Round | 24/03/2021 | CA Cerro | - | Cerro Largo | 0:1 | ||||
| 15. Round | 29/03/2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
Uruguay