| 1. Round | 01/02/2025 | Defensor Sporting | - | Boston River | 2:0 |  |
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| 2. Round | 09/02/2025 | Boston River | - | Montevideo City Torque | 0:0 | ||||
| 3. Round | 15/02/2025 | Peñarol | - | Boston River | 1:1 | ||||
| 5. Round | 09/03/2025 | Progreso | - | Boston River | 2:2 | ||||
| 7. Round | 22/03/2025 | Boston River | - | Racing | 1:3 | |
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| 8. Round | 26/03/2025 | Plaza Colonia | - | Boston River | 0:1 | ||||
| 9. Round | 29/03/2025 | Boston River | - | Liverpool | 0:1 |
Uruguay