| 1. Round | 24/01/2010 | Peñarol | - | Montevideo Wanderers | 4:2 | ||||
| 2. Round | 30/01/2010 | Rampla Juniors | - | Montevideo Wanderers | 2:1 | ||||
| 3. Round | 06/02/2010 | Fénix | - | Montevideo Wanderers | 2:1 | ||||
| 4. Round | 13/02/2010 | Montevideo Wanderers | - | Cerrito | 1:2 |  |
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| 5. Round | 21/02/2010 | Atenas | - | Montevideo Wanderers | 0:2 | ||||
| 6. Round | 27/02/2010 | Montevideo Wanderers | - | Central Español | 1:1 | ||||
| 7. Round | 06/03/2010 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 8. Round | 13/03/2010 | Montevideo Wanderers | - | Racing | 1:2 | ||||
| 9. Round | 21/03/2010 | CA Cerro | - | Montevideo Wanderers | 1:2 | ||||
| 10. Round | 28/03/2010 | Montevideo Wanderers | - | Danubio | 1:3 | ||||
| 11. Round | 04/04/2010 | Montevideo Wanderers | - | Cerro Largo | 7:1 | ||||
| 12. Round | 11/04/2010 | Liverpool | - | Montevideo Wanderers | 1:1 | ||||
| 13. Round | 18/04/2010 | Montevideo Wanderers | - | Tacuarembó | 2:1 | |
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| 14. Round | 25/04/2010 | Defensor Sporting | - | Montevideo Wanderers | 2:0 | ||||
| 15. Round | 02/05/2010 | Montevideo Wanderers | - | River Plate | 2:2 |
Uruguay