| 1. Round | 05/02/2017 | Plaza Colonia | - | Boston River | 0:0 |  |
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| 2. Round | 12/02/2017 | Boston River | - | River Plate | 2:0 | ||||
| 3. Round | 19/02/2017 | Peñarol | - | Boston River | 0:0 | ||||
| 4. Round | 25/02/2017 | Boston River | - | Racing | 0:1 | ||||
| 5. Round | 05/03/2017 | El Tanque Sisley | - | Boston River | 1:0 | |
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| 6. Round | 12/03/2017 | Boston River | - | Liverpool | 3:1 | ||||
| 7. Round | 18/03/2017 | CA Cerro | - | Boston River | 2:0 | ||||
| 8. Round | 25/03/2017 | Montevideo Wanderers | - | Boston River | 2:1 | |
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| 9. Round | 01/04/2017 | Boston River | - | Nacional | 3:1 | ||||
| 12. Round | 23/04/2017 | Defensor Sporting | - | Boston River | 1:0 | ||||
| 14. Round | 07/05/2017 | Juventud de Las Piedras | - | Boston River | 2:5 | |
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| 15. Round | 14/05/2017 | Boston River | - | Danubio | 0:3 | |
Uruguay