| 3. Round | 30/07/2022 | MFK Skalica | - | AS Trenčín | 2:0 | ||||
| 5. Round | 12/08/2022 | MFK Skalica | - | FK Železiarne Podbrezová | 1:1 | ||||
| 6. Round | 20/08/2022 | MFK Zemplín Michalovce | - | MFK Skalica | 3:1 | ||||
| 7. Round | 27/08/2022 | MFK Skalica | - | Spartak Trnava | 1:1 | ||||
| 9. Round | 03/09/2022 | Tatran Liptovský Mikuláš | - | MFK Skalica | 0:0 | ||||
| 11. Round | 16/09/2022 | Dukla Banská Bystrica | - | MFK Skalica | 0:0 | ||||
| 15. Round | 21/10/2022 | MFK Skalica | - | Slovan Bratislava | 1:4 | ||||
| 18. Round | 11/11/2022 | Spartak Trnava | - | MFK Skalica | 2:1 | ||||
| 19. Round | 11/02/2023 | MŠK Žilina | - | MFK Skalica | 1:0 | ||||
| 20. Round | 19/02/2023 | MFK Skalica | - | Tatran Liptovský Mikuláš | 3:0 | ||||
| 21. Round | 25/02/2023 | FC DAC 1904 | - | MFK Skalica | 2:1 | ||||
| 22. Round | 04/03/2023 | MFK Skalica | - | Dukla Banská Bystrica | 1:2 |
Slovakia