| 1. Round | 14/08/2021 | RCD Mallorca | - | Real Betis | 1:1 | ||||
| 2. Round | 20/08/2021 | Real Betis | - | Cádiz CF | 1:1 |  |
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| 3. Round | 28/08/2021 | Real Betis | - | Real Madrid | 0:1 | |
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| 6. Round | 23/09/2021 | CA Osasuna | - | Real Betis | 1:3 | ||||
| 11. Round | 27/10/2021 | Real Betis | - | Valencia CF | 4:1 | ||||
| 12. Round | 31/10/2021 | Atlético Madrid | - | Real Betis | 3:0 |
Spain
