3. Round | 22/01/2022 | UANL Tigres [] | - | Santos Laguna [] | 2:1 | ||||
4. Round | 29/01/2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:0 | ||||
5. Round | 04/02/2022 | Atlético San Luis [] | - | Santos Laguna [] | 0:2 | ||||
8. Round | 26/02/2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
15. Round | 20/04/2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 | ||||
16. Round | 23/04/2022 | Santos Laguna [] | - | UANL Tigres [] | 5:0 | ||||
17. Round | 30/04/2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 4:0 |