| 1. Round | 20/08/2017 | Rampla Juniors | - | Defensor Sporting | 2:2 | ||||
| 2. Round | 26/08/2017 | CA Cerro | - | Defensor Sporting | 0:3 | ||||
| 3. Round | 03/09/2017 | Defensor Sporting | - | Sud América | 3:2 | ||||
| 4. Round | 09/09/2017 | Juventud de Las Piedras | - | Defensor Sporting | 0:1 | ||||
| 5. Round | 16/09/2017 | Defensor Sporting | - | Danubio | 1:0 | ||||
| 7. Round | 14/10/2017 | Defensor Sporting | - | River Plate | 2:1 | ||||
| 8. Round | 05/11/2017 | Peñarol | - | Defensor Sporting | 3:1 | ||||
| 9. Round | 08/11/2017 | Defensor Sporting | - | Racing | 4:2 | ||||
| 10. Round | 12/11/2017 | El Tanque Sisley | - | Defensor Sporting | 0:2 | ||||
| 11. Round | 16/11/2017 | Defensor Sporting | - | Liverpool | 2:2 | ||||
| 12. Round | 19/11/2017 | Boston River | - | Defensor Sporting | 0:1 | ||||
| 13. Round | 23/11/2017 | Defensor Sporting | - | Montevideo Wanderers | 2:1 |  |
|||
| 15. Round | 03/12/2017 | Defensor Sporting | - | Fénix | 0:2 | |
Uruguay