| 5. Round | 15/02/2025 | Club Nacional | - | Guaraní | 1:2 | ||||
| 6. Round | 21/02/2025 | Guaraní | - | Deportivo Recoleta | 1:3 | ||||
| 13. Round | 14/04/2025 | General Caballero DJLM | - | Guaraní | 0:0 | ||||
| 14. Round | 16/04/2025 | Guaraní | - | 2 de Mayo | 0:1 | ||||
| 15. Round | 19/04/2025 | Libertad | - | Guaraní | 1:3 | ||||
| 16. Round | 26/04/2025 | Guaraní | - | Club Nacional | 2:1 | ||||
| 17. Round | 03/05/2025 | Deportivo Recoleta | - | Guaraní | 0:3 | ||||
| 18. Round | 10/05/2025 | Guaraní | - | Cerro Porteño | 0:2 |
Uruguay