| 1. Round | 03/06/2021 | Nacional | - | Cerro Largo | 1:2 | ||||
| 4. Round | 05/06/2021 | Plaza Colonia | - | Nacional | 1:2 | ||||
| 5. Round | 13/06/2021 | Nacional | - | Fénix | 3:1 | ||||
| 6. Round | 19/06/2021 | Boston River | - | Nacional | 1:1 | ||||
| 7. Round | 24/06/2021 | Nacional | - | Montevideo Wanderers | 3:0 | ||||
| 8. Round | 27/06/2021 | Rentistas | - | Nacional | 1:1 | ||||
| 15. Round | 21/08/2021 | River Plate | - | Nacional | 2:0 |  |
Uruguay