| 5. Round | 05/11/2000 | Panachaiki GE | - | Ionikos Nikea | 2:3 | ||||
| 6. Round | 11/11/2000 | Ionikos Nikea | - | PS Kalamata | 4:1 |  |
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| 7. Round | 19/11/2000 | PAS Giannina | - | Ionikos Nikea | 1:1 | ||||
| 8. Round | 25/11/2000 | Ionikos Nikea | - | Panionios GSS | 2:0 | ||||
| 9. Round | 02/12/2000 | Aris Saloniki | - | Ionikos Nikea | 0:0 |  |
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| 11. Round | 16/12/2000 | Ionikos Nikea | - | Paniliakos Pyrgos | 3:1 | ||||
| 12. Round | 02/01/2001 | Panathinaikos | - | Ionikos Nikea | 4:1 | ||||
| 16. Round | 27/01/2001 | Athinaikos | - | Ionikos Nikea | 2:2 | |
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| 20. Round | 24/02/2001 | Ionikos Nikea | - | Panachaiki GE | 3:1 | |
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| 22. Round | 10/03/2001 | Ionikos Nikea | - | PAS Giannina | 1:1 | |
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| 23. Round | 17/03/2001 | Panionios GSS | - | Ionikos Nikea | 4:0 | |
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| 24. Round | 01/04/2001 | Ionikos Nikea | - | Aris Saloniki | 2:1 | ||||
| 25. Round | 07/04/2001 | OFI Heraklion | - | Ionikos Nikea | 3:1 | ||||
| 26. Round | 19/04/2001 | Paniliakos Pyrgos | - | Ionikos Nikea | 1:0 | |
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| 29. Round | 20/05/2001 | Ionikos Nikea | - | Skoda Xanthi | 3:1 | |
Peru