| 1. Round | 18/01/2004 | Real San Luis | - | Club Necaxa | 0:2 | ||||
| 2. Round | 25/01/2004 | Puebla FC | - | Real San Luis | 1:2 |  |
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| 3. Round | 01/02/2004 | Real San Luis | - | Pumas UNAM | 0:0 | ||||
| 5. Round | 15/02/2004 | Real San Luis | - | Veracruz (old) | 0:0 | ||||
| 6. Round | 22/02/2004 | UAG Tecos | - | Real San Luis | 1:2 | ||||
| 7. Round | 26/02/2004 | Real San Luis | - | CF Monterrey | 1:1 | ||||
| 8. Round | 29/02/2004 | CF América | - | Real San Luis | 2:0 | ||||
| 9. Round | 07/03/2004 | Real San Luis | - | Atlas Guadalajara | 1:4 | ||||
| 10. Round | 14/03/2004 | Club Irapuato | - | Real San Luis | 3:1 | |
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| 11. Round | 21/03/2004 | Santos Laguna | - | Real San Luis | 2:0 |  |
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| 12. Round | 28/03/2004 | Real San Luis | - | Atlante | 0:0 | |
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| 13. Round | 04/04/2004 | Jaguares Chiapas | - | Real San Luis | 4:2 | |
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| 14. Round | 11/04/2004 | Real San Luis | - | CF Pachuca | 1:4 | ||||
| 15. Round | 18/04/2004 | Monarcas Morelia | - | Real San Luis | 2:1 | |
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| 16. Round | 25/04/2004 | Real San Luis | - | Gallos Blancos (old) | 3:0 | |
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| 17. Round | 01/05/2004 | UANL Tigres | - | Real San Luis | 3:3 | ||||
| 18. Round | 09/05/2004 | Real San Luis | - | Deportivo Toluca | 1:1 | |
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| 19. Round | 15/05/2004 | Deportivo Guadalajara | - | Real San Luis | 4:1 |
Uruguay