| 1. Round | 23/01/2010 | Atenas | - | Defensor Sporting | 3:1 | ||||
| 2. Round | 31/01/2010 | Defensor Sporting | - | Danubio | 0:1 | ||||
| 3. Round | 06/02/2010 | Nacional | - | Defensor Sporting | 0:1 |  |
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| 4. Round | 13/02/2010 | Defensor Sporting | - | Central Español | 3:4 | ||||
| 5. Round | 21/02/2010 | Fénix | - | Defensor Sporting | 3:0 | ||||
| 6. Round | 27/02/2010 | Defensor Sporting | - | Rampla Juniors | 2:1 | ||||
| 8. Round | 13/03/2010 | Cerro Largo | - | Defensor Sporting | 1:3 | |
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| 10. Round | 28/03/2010 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 11. Round | 03/04/2010 | Racing | - | Defensor Sporting | 3:3 | ||||
| 12. Round | 09/04/2010 | Defensor Sporting | - | CA Cerro | 1:0 | ||||
| 13. Round | 17/04/2010 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 14. Round | 25/04/2010 | Defensor Sporting | - | Montevideo Wanderers | 2:0 | ||||
| 15. Round | 02/05/2010 | Liverpool | - | Defensor Sporting | 3:0 |
Uruguay