| 1. Round | 05/02/2011 | Defensor Sporting | - | River Plate | 4:1 | ||||
| 2. Round | 12/02/2011 | Liverpool | - | Defensor Sporting | 1:2 | ||||
| 3. Round | 20/02/2011 | CA Cerro | - | Defensor Sporting | 2:1 | ||||
| 4. Round | 27/02/2011 | Montevideo Wanderers | - | Defensor Sporting | 0:1 | ||||
| 5. Round | 05/03/2011 | El Tanque Sisley | - | Defensor Sporting | 0:1 | ||||
| 6. Round | 13/03/2011 | Bella Vista | - | Defensor Sporting | 1:1 | ||||
| 7. Round | 19/03/2011 | Defensor Sporting | - | Miramar Misiones | 2:0 |  |
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| 8. Round | 02/04/2011 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 9. Round | 10/04/2011 | Rampla Juniors | - | Defensor Sporting | 0:0 | ||||
| 10. Round | 17/04/2011 | Fénix | - | Defensor Sporting | 0:1 | ||||
| 11. Round | 24/04/2011 | Defensor Sporting | - | Racing | 3:0 | ||||
| 12. Round | 07/05/2011 | Central Español | - | Defensor Sporting | 2:0 | ||||
| 13. Round | 22/05/2011 | Defensor Sporting | - | Peñarol | 1:1 | ||||
| 14. Round | 28/05/2011 | Nacional | - | Defensor Sporting | 3:0 | ||||
| 15. Round | 05/06/2011 | Defensor Sporting | - | Tacuarembó | 1:0 |
Uruguay