| 2. Round | 26/08/1980 | AFC Ajax | - | Roda JC Kerkrade | 4:2 |  |
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| 3. Round | 29/08/1980 | AFC Ajax | - | FC Wageningen | 2:4 | ||||
| 4. Round | 02/09/1980 | NAC Breda | - | AFC Ajax | 1:1 | ||||
| 5. Round | 13/09/1980 | AFC Ajax | - | PSV Eindhoven | 5:2 | ||||
| 6. Round | 20/09/1980 | SBV Excelsior | - | AFC Ajax | 2:4 | ||||
| 7. Round | 27/09/1980 | AFC Ajax | - | FC Groningen | 5:1 | ||||
| 10. Round | 25/10/1980 | PEC Zwolle | - | AFC Ajax | 2:0 | ||||
| 11. Round | 28/10/1980 | AFC Ajax | - | SC NEC | 2:0 | ||||
| 12. Round | 08/11/1980 | Sparta Rotterdam | - | AFC Ajax | 4:3 | ||||
| 13. Round | 21/11/1980 | MVV | - | AFC Ajax | 1:1 | ||||
| 14. Round | 29/11/1980 | AFC Ajax | - | FC Twente | 5:3 | ||||
| 30. Round | 09/05/1981 | AFC Ajax | - | MVV | 6:1 | ||||
| 21. Round | 11/05/1981 | AFC Ajax | - | NAC Breda | 4:1 | ||||
| 31. Round | 16/05/1981 | FC Twente | - | AFC Ajax | 3:0 | ||||
| 32. Round | 23/05/1981 | AFC Ajax | - | Feyenoord | 4:1 | ||||
| 33. Round | 29/05/1981 | Willem II | - | AFC Ajax | 1:3 | ||||
| 34. Round | 05/06/1981 | AFC Ajax | - | FC Utrecht | 1:0 |
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