| 1. Round | 24/07/2021 | Tatran Liptovský Mikuláš | - | Slovan Bratislava | 1:4 | ||||
| 2. Round | 01/08/2021 | FC DAC 1904 | - | Tatran Liptovský Mikuláš | 3:1 | ||||
| 6. Round | 28/08/2021 | Tatran Liptovský Mikuláš | - | FK Senica | 1:2 | ||||
| 9. Round | 25/09/2021 | Zlaté Moravce | - | Tatran Liptovský Mikuláš | 2:2 | ||||
| 10. Round | 02/10/2021 | MFK Ružomberok | - | Tatran Liptovský Mikuláš | 4:1 |  |
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| 13. Round | 30/10/2021 | Tatran Liptovský Mikuláš | - | FC DAC 1904 | 1:0 | ||||
| 14. Round | 07/11/2021 | Tatran Liptovský Mikuláš | - | Spartak Trnava | 0:2 | ||||
| 17. Round | 04/12/2021 | FK Senica | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 18. Round | 11/12/2021 | Tatran Liptovský Mikuláš | - | ŠKF Sereď | 1:1 | ||||
| 19. Round | 18/12/2021 | FK Pohronie | - | Tatran Liptovský Mikuláš | 2:2 |
Czech Republic