| 1. Round | 13/07/2019 | Guaraní | - | River Plate | 1:3 |  |
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| 2. Round | 21/07/2019 | River Plate | - | Sol de América | 2:2 | ||||
| 3. Round | 27/07/2019 | Club Olimpia | - | River Plate | 2:1 | ||||
| 4. Round | 03/08/2019 | River Plate | - | Club Nacional | 0:1 | ||||
| 5. Round | 10/08/2019 | General Díaz | - | River Plate | 1:1 | ||||
| 8. Round | 03/09/2019 | Cerro Porteño | - | River Plate | 2:0 | ||||
| 11. Round | 24/09/2019 | River Plate | - | San Lorenzo | 0:0 | |
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| 14. Round | 20/10/2019 | River Plate | - | Club Olimpia | 0:1 | |
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| 16. Round | 02/11/2019 | River Plate | - | General Díaz | 1:0 | ||||
| 17. Round | 23/11/2019 | River Plate | - | Libertad | 0:2 | |
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| 20. Round | 30/11/2019 | Deportivo Santaní | - | River Plate | 0:1 |
Argentina